Carranza’s Clinical Periodontology, 12th Ed-Chapter 11

Caption: Figure 11-24: Papillon-Lefèvre syndrome in a 17-year-old boy. A, A clinical view of the palms demonstrates hyperkeratosis of skin. B, A clinical view of the knees, which have hyperkeratotic scaly lesions.

Insight: Chronic periodontitis is a common finding in conditions and syndromes characterized by defective immune cells.  This is the case in Papillon-Lefèvre syndrome, where the defect lies in the neutrophil function. Due to the extensive extra-oral manifestation of this syndrome, it is a good example that underscores the importance of doing a thorough intra and extra-oral examination as part of periodontal evaluation. This will allow us to arrive at the correct diagnosis followed by referral and/or treatment.

Carranza’s Clinical Periodontology, 12th Ed
Chapter 11. Influence of Systemic Conditions
Perry R. Lokkevold
Brian L. Mealey